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KMID : 0363720090420030141
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Korean Journal of Anatomy
2009 Volume.42 No. 3 p.141 ~ p.147
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Streptozotocin-induced Diabetes Increases the Adiponectin-mediated AMP-activated Protein Kinase Cascade in the Hippocampus of Mice
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Yi Chin-Ok
Jeon Byeong-Tak
Kim Young-Hee
Jung Tae-Sik
Lee Dong-Hoon
Kim Hyun-Joon
Kang Sang-Soo
Cho Gyeong-Jae
Choi Wan-Sung
Roh Gu-Seob
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Abstract
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Adiponectin is an adipocyte-derived protein with anti-diabetic and anti-angiogenesis properties that improves both glucose metabolism and insulin resistance via the adenosine monophosphate-activated protein kinase (AMPK) cascade. Diabetic cognitive deficits are correlated with dysregulation of energy metabolism in the hippocampus. In the present study, we investigated the expression of adiponectin-mediated AMPK cascade proteins in the hippocampus of streptozotocin (STZ)-induced diabetic mice. Diabetes was induced by STZ (55 mg/kg) injection intraperitoneally. Twenty-four weeks after induction of diabetes, mice were sacrificed. Results showed that decreased serum adiponectin levels and increased expression of hippocampal adiponectin receptor 1 (AdipoR1) was expressed in diabetic mice. Phosphorylated AMPK, acetyl CoA carboxylase (ACC), and eNOS expression levels were increased in the hippocampus of diabetic mice. The immunoreactivity of glucose transporter 1 in the endothelium of hippocampal blood vessels was also increased. These results indicate that adiponectin-mediated AMPK cascade activation may play a role in catabolic process that is involved in diabetic neurodegeneration.
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KEYWORD
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Streptozotocin, Adiponectin, AMPK, Diabetes, Hippocampus, Mouse
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